Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
P43243
UPID:
MATR3_HUMAN
Alternative names:
-
Alternative UPACC:
P43243; B7ZAV5; D3DQC3; Q9UHW0; Q9UQ27
Background:
Matrin-3, encoded by the gene with accession number P43243, is implicated in various cellular processes, including transcription regulation and the formation of the internal fibrogranular network. It interacts with nuclear matrix proteins and plays a pivotal role in the nuclear retention of defective RNAs. Matrin-3 is also involved in the innate immune response against DNA viruses by participating in the HDP-RNP complex, crucial for IRF3 phosphorylation through the cGAS-STING pathway. Additionally, it binds to m6A-containing mRNAs, influencing MYC stability and may interact with specific miRNA hairpins.
Therapeutic significance:
Matrin-3's association with Amyotrophic lateral sclerosis 21, a neurodegenerative disorder characterized by muscle weakness and respiratory failure, underscores its potential as a target for therapeutic intervention. Understanding the role of Matrin-3 could open doors to potential therapeutic strategies.