Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Several key aspects differentiate our library:
partner
Reaxense
upacc
Q8NEW7
UPID:
TMIE_HUMAN
Alternative names:
-
Alternative UPACC:
Q8NEW7; A0AV93; A8K0R0
Background:
The Transmembrane inner ear expressed protein, with accession number Q8NEW7, is implicated in critical cellular processes, including protein and vesicle trafficking. Its localization within internal membrane compartments or the plasma membrane suggests a versatile role in cellular dynamics, facilitated by its highly charged C-terminal domain.
Therapeutic significance:
Linked to Deafness, autosomal recessive, 6, this protein's malfunction underscores its potential as a target for therapeutic intervention. Understanding its role could pave the way for innovative treatments in sensorineural hearing loss.