Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q9BZE0
UPID:
GLIS2_HUMAN
Alternative names:
GLI-similar 2; Neuronal Krueppel-like protein
Alternative UPACC:
Q9BZE0; B3KX84
Background:
Zinc finger protein GLIS2, also known as GLI-similar 2 or Neuronal Krueppel-like protein, plays a pivotal role in cellular processes. It can function as both a transcriptional repressor and activator, influencing the Hedgehog signaling pathway and the Wnt signaling pathway. Its activity is crucial for maintaining the differentiated epithelial phenotype in renal cells and may be involved in neuron differentiation.
Therapeutic significance:
GLIS2's involvement in Nephronophthisis 7, a severe renal disorder, underscores its therapeutic significance. Understanding the role of Zinc finger protein GLIS2 could open doors to potential therapeutic strategies for this and possibly other related diseases.