Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
Q9H334
UPID:
FOXP1_HUMAN
Alternative names:
Mac-1-regulated forkhead
Alternative UPACC:
Q9H334; A3QVP8; B3KV70; G5E9V8; Q8NAN6; Q9BSG9; Q9H332; Q9H333; Q9P0R1
Background:
Forkhead box protein P1, also known as Mac-1-regulated forkhead, plays a pivotal role in various biological processes. It functions as a transcriptional repressor, essential in lung epithelium differentiation, B-cell development, and spinal motor neuron organization. Its involvement extends to embryonic stem cell pluripotency, hair follicle stem cell quiescence, and angiogenesis, showcasing its broad regulatory capabilities.
Therapeutic significance:
The association of Forkhead box protein P1 with Intellectual developmental disorder with language impairment and autistic features highlights its therapeutic potential. Understanding its role could pave the way for innovative treatments targeting this and possibly other related disorders.