Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
Q9Y698
UPID:
CCG2_HUMAN
Alternative names:
Neuronal voltage-gated calcium channel gamma-2 subunit; Transmembrane AMPAR regulatory protein gamma-2
Alternative UPACC:
Q9Y698; Q2M1M1; Q5TGT3; Q9UGZ7
Background:
The Voltage-dependent calcium channel gamma-2 subunit, also known as Neuronal voltage-gated calcium channel gamma-2 subunit and Transmembrane AMPAR regulatory protein gamma-2, plays a crucial role in the nervous system. It regulates AMPA-selective glutamate receptors, influencing their cell membrane targeting and synaptic properties, and modulates their activation, deactivation, and desensitization rates. This protein is essential for stabilizing calcium channels in their closed state.
Therapeutic significance:
Linked to Intellectual developmental disorder, autosomal dominant 10, this protein's understanding could pave the way for innovative treatments. Its role in regulating glutamate receptors and calcium channels highlights its potential as a target for therapeutic intervention in intellectual developmental disorders.