Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Several key aspects differentiate our library:
partner
Reaxense
upacc
A0PJY2
UPID:
FEZF1_HUMAN
Alternative names:
Zinc finger protein 312B
Alternative UPACC:
A0PJY2; A0PJY3; A4D0W3; B4DUP9; B7ZM98
Background:
Fez family zinc finger protein 1, also known as Zinc finger protein 312B, plays a crucial role in the development of the nervous system. It is involved in axonal projection, termination of olfactory sensory neurons, and patterning of the diencephalon. Its expression is vital for the regulation of olfactory bulb development and interneuron migration.
Therapeutic significance:
The protein is linked to Hypogonadotropic hypogonadism 22 with or without anosmia, a condition affecting sexual maturation and olfactory function. Understanding the role of Fez family zinc finger protein 1 could open doors to potential therapeutic strategies for this disorder.