Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
A1L188
UPID:
NDUF8_HUMAN
Alternative names:
-
Alternative UPACC:
A1L188
Background:
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 8 plays a crucial role in the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I, MT-ND1), essential for cellular energy production. It stabilizes NDUFAF5, highlighting its importance in mitochondrial function.
Therapeutic significance:
Linked to Mitochondrial complex I deficiency, nuclear type 34, a condition with a broad spectrum of severity, this protein's dysfunction can lead to various diseases, including neurodegenerative disorders and cardiomyopathy. Understanding its role could lead to novel therapeutic strategies for these conditions.