Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
A5YKK6
UPID:
CNOT1_HUMAN
Alternative names:
CCR4-associated factor 1; Negative regulator of transcription subunit 1 homolog
Alternative UPACC:
A5YKK6; Q68DX7; Q7Z3K2; Q8IWB8; Q8TB53; Q9BVZ6; Q9UFR8; Q9UI27; Q9Y2L0
Background:
CCR4-NOT transcription complex subunit 1, also known as CCR4-associated factor 1, plays a pivotal role in mRNA degradation, miRNA-mediated repression, and transcription regulation. It functions as a scaffolding component of the CCR4-NOT complex, influencing mRNA expression through interactions with RNA-binding proteins and the catalytic complex module.
Therapeutic significance:
Linked to Holoprosencephaly 12 and Vissers-Bodmer syndrome, CCR4-NOT transcription complex subunit 1's involvement in these diseases highlights its potential as a target for therapeutic intervention. Understanding its role could open doors to novel treatments for these genetic disorders.