Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Several key aspects differentiate our library:
partner
Reaxense
upacc
C9JE40
UPID:
PATL2_HUMAN
Alternative names:
PAT1-like protein 2; Protein PAT1 homolog a
Alternative UPACC:
C9JE40
Background:
Protein PAT1 homolog 2, also known as PAT1-like protein 2 and Protein PAT1 homolog a, plays a crucial role in cellular processes as an RNA-binding protein that acts as a translational repressor. Its involvement in the regulation of RNA stability and translation underscores its importance in cellular homeostasis and developmental processes.
Therapeutic significance:
The protein is directly linked to Oocyte/zygote/embryo maturation arrest 4, an autosomal recessive infertility disorder. This association highlights the protein's critical role in reproductive health, specifically in oocyte maturation and early embryonic development. Understanding the role of Protein PAT1 homolog 2 could open doors to potential therapeutic strategies for treating infertility disorders.