Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
D6RGH6
UPID:
MCIN_HUMAN
Alternative names:
Multiciliate differentiation and DNA synthesis-associated cell cycle protein; Protein Idas
Alternative UPACC:
D6RGH6; C9JGY3; D6R920; F8KGQ8
Background:
Multicilin, known alternatively as Multiciliate differentiation and DNA synthesis-associated cell cycle protein or Protein Idas, plays a pivotal role in multiciliate cell differentiation. It is part of a complex with E2F4 and E2F5, activating genes essential for centriole biogenesis and the acentriolar pathway. Additionally, it influences mitotic cell cycle progression and modulates GMNN activity, impacting CDT1 affinity.
Therapeutic significance:
Linked to Ciliary dyskinesia, primary, 42, a disorder marked by motile cilia abnormalities leading to respiratory infections and potentially infertility and hydrocephalus, Multicilin's study could pave the way for innovative treatments targeting these cilia-related conditions.