Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
O00292
UPID:
LFTY2_HUMAN
Alternative names:
Endometrial bleeding-associated factor; Left-right determination factor A; Protein lefty-2; Protein lefty-A; Transforming growth factor beta-4
Alternative UPACC:
O00292; B3KNH4; B4E332; E9PDM4; O75611; Q5TE89; Q8NBQ9
Background:
Left-right determination factor 2, also known as Protein lefty-2 or Transforming growth factor beta-4, plays a crucial role in establishing left-right (L-R) asymmetry in organ systems of mammals. It is also implicated in endometrial bleeding, highlighting its diverse biological functions.
Therapeutic significance:
The protein's involvement in left-right axis malformations, including severe cardiac anomalies and interrupted inferior vena cava, underscores its potential as a target for therapeutic intervention. Understanding the role of Left-right determination factor 2 could open doors to potential therapeutic strategies for these congenital conditions.