Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
O00303
UPID:
EIF3F_HUMAN
Alternative names:
Deubiquitinating enzyme eIF3f; Eukaryotic translation initiation factor 3 subunit 5; eIF-3-epsilon; eIF3 p47
Alternative UPACC:
O00303; A8K0S2; Q6IB45; Q8N978
Background:
Eukaryotic translation initiation factor 3 subunit F (eIF3f) plays a crucial role in the initiation of protein synthesis by forming part of the eIF-3 complex. This complex is essential for several steps in the initiation process, including mRNA recruitment and scanning for AUG recognition. eIF3f is also involved in the regulation of cell proliferation, differentiation, and apoptosis through its specific targeting and initiation of translation of certain mRNAs.
Therapeutic significance:
The association of eIF3f with Intellectual developmental disorder, autosomal recessive 67, highlights its potential as a target for therapeutic intervention. Understanding the role of eIF3f could open doors to potential therapeutic strategies.