Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
Our top-notch dedicated system is used to design specialised libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
The method includes detailed molecular simulations of the catalytic and allosteric binding pockets, along with ensemble virtual screening that considers their conformational flexibility. In the design of modulators, structural changes induced by reaction intermediates are taken into account to enhance activity and selectivity.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
O00429
UPID:
DNM1L_HUMAN
Alternative names:
Dnm1p/Vps1p-like protein; Dynamin family member proline-rich carboxyl-terminal domain less; Dynamin-like protein; Dynamin-like protein 4; Dynamin-like protein IV; Dynamin-related protein 1
Alternative UPACC:
O00429; A8K4X9; B4DGC9; B4DSU8; G8JLD5; J3KPI2; O14541; O60709; Q59GN9; Q7L6B3; Q8TBT7; Q9BWM1; Q9Y5J2
Background:
Dynamin-1-like protein, also known as Dnm1p/Vps1p-like protein, plays a pivotal role in mitochondrial and peroxisomal division. It orchestrates membrane fission through GTP hydrolysis-dependent mechanisms, ensuring cellular health and proper organelle distribution. Its involvement in synaptic vesicle dynamics and apoptosis underscores its multifunctionality in cellular processes.
Therapeutic significance:
Linked to Encephalopathy due to defective mitochondrial and peroxisomal fission 1 and Optic atrophy 5, Dynamin-1-like protein's dysfunction highlights its critical role in neurodevelopment and vision. Understanding its mechanisms opens avenues for targeted therapies in mitochondrial-related disorders.