Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our top-notch dedicated system is used to design specialised libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
This approach involves comprehensive molecular simulations of the catalytic and allosteric binding pockets and ensemble virtual screening that accounts for their conformational flexibility. In the case of designing modulators, the structural adjustments caused by reaction intermediates are considered to improve activity and selectivity.
Our library stands out due to several important features:
partner
Reaxense
upacc
O14607
UPID:
UTY_HUMAN
Alternative names:
Ubiquitously-transcribed TPR protein on the Y chromosome; Ubiquitously-transcribed Y chromosome tetratricopeptide repeat protein; [histone H3]-trimethyl-L-lysine(27) demethylase UTY
Alternative UPACC:
O14607; A8K9Z3; E1U199; E1U1A0; F5H4V7; F8W8R7; O14608
Background:
Histone demethylase UTY, also known as ubiquitously-transcribed TPR protein on the Y chromosome, plays a crucial role in epigenetic regulation by catalyzing the demethylation of trimethylated 'Lys-27' on histone H3. This specific activity is pivotal for the regulation of gene expression, impacting male-specific biological processes.
Therapeutic significance:
Understanding the role of Histone demethylase UTY could open doors to potential therapeutic strategies. Its involvement in epigenetic modifications suggests a foundational role in gene expression regulation, which could be pivotal for developing treatments targeting epigenetic disorders.