Focused On-demand Library for Actin-related protein 2/3 complex subunit 1B

Focused On-demand Libraries - Reaxense Collaboration

Explore the Potential with AI-Driven Innovation

This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.

From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.

The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.

Our top-notch dedicated system is used to design specialised libraries.

Fig. 1. The sreening workflow of Receptor.AI

Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.

Our library is unique due to several crucial aspects:

Receptor.AI compiles all relevant data on the target protein, such as past experimental results, literature findings, known ligands, and structural data, thereby enhancing the likelihood of focusing on the most significant compounds.
By utilizing advanced molecular simulations, the platform is adept at locating potential binding sites, rendering the compounds in the focused library well-suited for unearthing allosteric inhibitors and binders for hidden pockets.
The platform is supported by more than 50 highly specialized AI models, all of which have been rigorously tested and validated in diverse drug discovery and research programs. Its design emphasizes efficiency, reliability, and accuracy, crucial for producing focused libraries.
Receptor.AI extends beyond just creating focused libraries; it offers a complete spectrum of services and solutions during the preclinical drug discovery phase, with a success-dependent pricing strategy that reduces risk and fosters shared success in the project.

partner

Reaxense

upacc

O15143

UPID:

ARC1B_HUMAN

Alternative names:

Arp2/3 complex 41 kDa subunit; p41-ARC

Alternative UPACC:

O15143; Q9BU00

Background:

Actin-related protein 2/3 complex subunit 1B, also known as Arp2/3 complex 41 kDa subunit or p41-ARC, plays a pivotal role in cellular dynamics. It is a key component of the Arp2/3 complex, crucial for actin polymerization and the formation of branched actin networks in the cytoplasm. This process is essential for cell motility. Additionally, the Arp2/3 complex is involved in nuclear functions, including gene transcription and DNA repair, particularly through promoting homologous recombination repair in response to DNA damage.

Therapeutic significance:

The protein's involvement in Immunodeficiency 71 with inflammatory disease and congenital thrombocytopenia highlights its potential as a therapeutic target. Understanding the role of Actin-related protein 2/3 complex subunit 1B could open doors to potential therapeutic strategies for treating this genetic disorder and possibly other related inflammatory diseases.