Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
O15273
UPID:
TELT_HUMAN
Alternative names:
Titin cap protein
Alternative UPACC:
O15273; Q96L27
Background:
Telethonin, also known as the Titin cap protein, plays a pivotal role in muscle assembly, specifically mediating the antiparallel assembly of titin molecules at the sarcomeric Z-disk. This process is crucial for the structural integrity and function of striated muscles.
Therapeutic significance:
Telethonin is implicated in serious conditions such as Cardiomyopathy, familial hypertrophic, 25, and Muscular dystrophy, limb-girdle, autosomal recessive 7. These associations highlight its potential as a target for therapeutic interventions aimed at mitigating heart and muscle disorders.