Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
Our top-notch dedicated system is used to design specialised libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
It includes comprehensive molecular simulations of the catalytic and allosteric binding pockets and the ensemble virtual screening accounting for their conformational mobility. In the case of designing modulators, the structural changes induced by reaction intermediates are taken into account to leverage activity and selectivity.
Key features that set our library apart include:
partner
Reaxense
upacc
O15344
UPID:
TRI18_HUMAN
Alternative names:
Midin; Putative transcription factor XPRF; RING finger protein 59; RING finger protein Midline-1; RING-type E3 ubiquitin transferase Midline-1; Tripartite motif-containing protein 18
Alternative UPACC:
O15344; B2RCG2; O75361; Q9BZX5
Background:
E3 ubiquitin-protein ligase Midline-1, known by alternative names such as Midin and RING finger protein Midline-1, plays a crucial role in cellular processes through its E3 ubiquitin ligase activity towards IGBP1. This activity promotes monoubiquitination leading to significant cellular outcomes, including the degradation of protein phosphatase PP2A's catalytic subunit.
Therapeutic significance:
The protein's mutation is directly linked to Opitz GBBB syndrome, a congenital disorder presenting a spectrum of physical and developmental challenges. Understanding the role of E3 ubiquitin-protein ligase Midline-1 could open doors to potential therapeutic strategies for managing and treating this complex syndrome.