Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
O15389
UPID:
SIGL5_HUMAN
Alternative names:
CD33 antigen-like 2; Obesity-binding protein 2
Alternative UPACC:
O15389
Background:
Sialic acid-binding Ig-like lectin 5, also known as CD33 antigen-like 2 or Obesity-binding protein 2, is a putative adhesion molecule. It mediates sialic-acid dependent binding to cells, recognizing both alpha-2,3-linked and alpha-2,6-linked sialic acid. The sialic acid recognition site of this protein may be masked by cis interactions with sialic acids on the same cell surface.
Therapeutic significance:
Understanding the role of Sialic acid-binding Ig-like lectin 5 could open doors to potential therapeutic strategies.