Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We use our state-of-the-art dedicated workflow for designing focused libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
The procedure entails thorough molecular simulations of the catalytic and allosteric binding pockets, accompanied by ensemble virtual screening that factors in their conformational flexibility. When developing modulators, the structural modifications brought about by reaction intermediates are factored in to optimize activity and selectivity.
Our library stands out due to several important features:
partner
Reaxense
upacc
O43173
UPID:
SIA8C_HUMAN
Alternative names:
Alpha-2,8-sialyltransferase 8C; Alpha-2,8-sialyltransferase III; ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3; Sialyltransferase 8C; Sialyltransferase St8Sia III
Alternative UPACC:
O43173; A8K0F2; Q6B085; Q9NS41
Background:
Sia-alpha-2,3-Gal-beta-1,4-GlcNAc-R:alpha 2,8-sialyltransferase, also known as Alpha-2,8-sialyltransferase 8C, plays a crucial role in the biosynthesis of glycoproteins and glycolipids. It catalyzes the transfer of sialic acid onto the terminal sialic acid of acceptors, displaying a preference for substrates with alpha-2,3-linked terminal sialic acid. This enzyme is capable of forming polysialic acid in vitro on various sialic acid linkages.
Therapeutic significance:
Understanding the role of Sia-alpha-2,3-Gal-beta-1,4-GlcNAc-R:alpha 2,8-sialyltransferase could open doors to potential therapeutic strategies.