Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Several key aspects differentiate our library:
partner
Reaxense
upacc
O43511
UPID:
S26A4_HUMAN
Alternative names:
Sodium-independent chloride/iodide transporter; Solute carrier family 26 member 4
Alternative UPACC:
O43511; B7Z266; O43170
Background:
Pendrin, identified by the gene symbol SLC26A4, functions as a sodium-independent transporter of chloride and iodide. It plays a crucial role in mediating electroneutral exchange of chloride-bicarbonate, chloride-iodide, and chloride-formate, as well as iodide-bicarbonate exchange. This protein's alternative names include Sodium-independent chloride/iodide transporter and Solute carrier family 26 member 4.
Therapeutic significance:
Pendrin is implicated in Pendred syndrome, a disorder characterized by congenital sensorineural hearing loss and thyroid goiter, and in non-syndromic sensorineural deafness associated with an enlarged vestibular aqueduct. Understanding the role of Pendrin could open doors to potential therapeutic strategies for these conditions.