Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
O60481
UPID:
ZIC3_HUMAN
Alternative names:
Zinc finger protein 203; Zinc finger protein of the cerebellum 3
Alternative UPACC:
O60481; B2CNW4; Q14DE5; Q5JY75
Background:
Zinc finger protein ZIC 3, also known as Zinc finger protein 203 and Zinc finger protein of the cerebellum 3, plays a pivotal role in axial midline development and left-right asymmetry specification. It acts as a transcriptional activator, binding to the GLI-consensus sequence, essential for early developmental stages.
Therapeutic significance:
ZIC 3 is implicated in several congenital disorders, including Heterotaxy, visceral, 1, X-linked; VACTERL association X-linked with or without hydrocephalus; and multiple types of Congenital heart defects. Understanding the role of Zinc finger protein ZIC 3 could open doors to potential therapeutic strategies for these complex conditions.