Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
Our top-notch dedicated system is used to design specialised libraries for receptors.
Fig. 1. The sreening workflow of Receptor.AI
This process includes extensive molecular simulations of the receptor in its native membrane environment, along with ensemble virtual screening that accounts for its conformational mobility. In the case of dimeric or oligomeric receptors, the entire functional complex is modelled, identifying potential binding pockets on and between the subunits to encompass all possible mechanisms of action.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
O75311
UPID:
GLRA3_HUMAN
Alternative names:
-
Alternative UPACC:
O75311; D3DP44; O75816; Q5D0E3
Background:
Glycine receptor subunit alpha-3 is a pivotal component of glycine receptors, which are ligand-gated chloride channels. These channels, activated by extracellular glycine, play a crucial role in modulating neuronal excitability and are involved in generating inhibitory postsynaptic currents. Their function is influenced by subunit composition, with heteropentameric channels exhibiting faster closure.
Therapeutic significance:
Understanding the role of Glycine receptor subunit alpha-3 could open doors to potential therapeutic strategies. Its involvement in down-regulating neuronal excitability and contributing to pain perception highlights its potential as a target in treating neurological disorders and pain management.