Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Several key aspects differentiate our library:
partner
Reaxense
upacc
O75360
UPID:
PROP1_HUMAN
Alternative names:
Pituitary-specific homeodomain factor
Alternative UPACC:
O75360
Background:
The Homeobox protein prophet of Pit-1, also known as the Pituitary-specific homeodomain factor, plays a crucial role in the development of various pituitary cell types. It is instrumental in the ontogenesis of pituitary gonadotropes, somatotropes, lactotropes, and caudomedial thyrotropes.
Therapeutic significance:
Linked to Combined Pituitary Hormone Deficiency (CPHD2), this protein's dysfunction results in a spectrum of hormone deficiencies. Understanding its role could lead to novel treatments for CPHD2, enhancing hormone replacement therapies.