Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
Our top-notch dedicated system is used to design specialised libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
It includes comprehensive molecular simulations of the catalytic and allosteric binding pockets and the ensemble virtual screening accounting for their conformational mobility. In the case of designing modulators, the structural changes induced by reaction intermediates are taken into account to leverage activity and selectivity.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
O75792
UPID:
RNH2A_HUMAN
Alternative names:
Aicardi-Goutieres syndrome 4 protein; RNase H(35); Ribonuclease HI large subunit; Ribonuclease HI subunit A
Alternative UPACC:
O75792; B2RCY1; Q96F11
Background:
Ribonuclease H2 subunit A, also known as Aicardi-Goutieres syndrome 4 protein, plays a pivotal role in DNA replication. It specifically degrades the RNA of RNA:DNA hybrids, facilitating the removal of RNA primers during DNA replication and excising single ribonucleotides from DNA:RNA duplexes.
Therapeutic significance:
Linked to Aicardi-Goutieres syndrome 4, a severe neurological disorder, understanding Ribonuclease H2 subunit A's function could pave the way for innovative treatments. Its role in DNA replication and repair mechanisms positions it as a potential target for therapeutic intervention.