Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
O95475
UPID:
SIX6_HUMAN
Alternative names:
Homeodomain protein OPTX2; Optic homeobox 2; Sine oculis homeobox homolog 6
Alternative UPACC:
O95475; Q6NT42; Q9P1X8
Background:
The Homeobox protein SIX6, also known as Homeodomain protein OPTX2, Optic homeobox 2, and Sine oculis homeobox homolog 6, plays a crucial role in eye development. This protein, encoded by the gene with the accession number O95475, is implicated in the intricate processes that shape the human eye, guiding the formation of key optical structures.
Therapeutic significance:
SIX6 is directly associated with Optic disk anomalies with retinal and/or macular dystrophy, a condition marked by optic nerve dysplasia, optic disk anomalies, chorioretinal dystrophy, and macular atrophy. Understanding the role of Homeobox protein SIX6 could open doors to potential therapeutic strategies for this ocular disorder, offering hope for targeted interventions.