Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
Our top-notch dedicated system is used to design specialised libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
This approach involves comprehensive molecular simulations of the catalytic and allosteric binding pockets and ensemble virtual screening that accounts for their conformational flexibility. In the case of designing modulators, the structural adjustments caused by reaction intermediates are considered to improve activity and selectivity.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
P00747
UPID:
PLMN_HUMAN
Alternative names:
-
Alternative UPACC:
P00747; Q15146; Q5TEH4; Q6PA00
Background:
Plasminogen, a critical protein, plays a pivotal role in fibrinolysis, the process of breaking down fibrin blood clots. Beyond its well-known function in clot dissolution, plasminogen is instrumental in various physiological processes including tissue remodeling, embryonic development, and the modulation of inflammation. Its ability to activate several proteolytic factors and cleave components like fibronectin and laminin underscores its importance in cellular functions.
Therapeutic significance:
Plasminogen deficiency, manifesting in two forms, underscores the protein's clinical relevance. Type 1 deficiency leads to severe fibrinolysis impairment and chronic mucosal lesions, with ligneous conjunctivitis being a hallmark symptom. Additionally, plasminogen's role in hereditary angioedema highlights its potential as a therapeutic target. Understanding the multifaceted functions of plasminogen could pave the way for innovative treatments for these conditions.