Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
Our top-notch dedicated system is used to design specialised libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
This approach involves comprehensive molecular simulations of the catalytic and allosteric binding pockets and ensemble virtual screening that accounts for their conformational flexibility. In the case of designing modulators, the structural adjustments caused by reaction intermediates are considered to improve activity and selectivity.
Key features that set our library apart include:
partner
Reaxense
upacc
P01133
UPID:
EGF_HUMAN
Alternative names:
-
Alternative UPACC:
P01133; B4DRK7; E7EVD2; E9PBF0; Q52LZ6
Background:
The Pro-epidermal growth factor (EGF) plays a pivotal role in cellular growth, proliferation, and differentiation. It activates epidermal growth factor receptor (EGFR) pathways, influencing various biological processes. Notably, it facilitates magnesium reabsorption in the kidneys and can induce neurite outgrowth, showcasing its diverse biological impact.
Therapeutic significance:
Hypomagnesemia 4, a disorder linked to mutations in the gene encoding Pro-epidermal growth factor, underscores the protein's clinical relevance. Understanding the role of Pro-epidermal growth factor could open doors to potential therapeutic strategies, particularly in managing renal magnesium handling and neurological development.