Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
P01270
UPID:
PTHY_HUMAN
Alternative names:
Parathormone; Parathyrin
Alternative UPACC:
P01270; Q4VB48; Q9UD38
Background:
Parathyroid hormone, also known as Parathormone or Parathyrin, plays a crucial role in regulating calcium levels in the blood. By dissolving bone salts and preventing their renal excretion, it elevates calcium levels, essential for various bodily functions including bone formation and maintenance.
Therapeutic significance:
The protein's involvement in Hypoparathyroidism, familial isolated, 1, a condition characterized by hypocalcemia and hyperphosphatemia, underscores its therapeutic significance. Understanding the role of Parathyroid hormone could open doors to potential therapeutic strategies for managing this disorder.