Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
P02787
UPID:
TRFE_HUMAN
Alternative names:
Beta-1 metal-binding globulin; Siderophilin
Alternative UPACC:
P02787; O43890; Q1HBA5; Q9NQB8; Q9UHV0
Background:
Serotransferrin, also known as Beta-1 metal-binding globulin or Siderophilin, is a pivotal iron-binding transport protein. It plays a crucial role in the transport of iron across the body, facilitating the movement of iron from absorption sites to storage and utilization areas. This protein's ability to bind two Fe(3+) ions alongside an anion, typically bicarbonate, underscores its significance in iron metabolism. Additionally, serotransferrin stimulates cell proliferation, highlighting its multifaceted biological functions.
Therapeutic significance:
The association of Serotransferrin with Atransferrinemia, a rare autosomal recessive disorder characterized by iron overload and microcytic hypochromic anemia, underscores its therapeutic significance. This connection opens avenues for targeted therapeutic strategies aimed at correcting the abnormal synthesis of transferrin, thereby addressing the underlying cause of iron dysregulation in Atransferrinemia.