Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We use our state-of-the-art dedicated workflow for designing focused libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
The procedure entails thorough molecular simulations of the catalytic and allosteric binding pockets, accompanied by ensemble virtual screening that factors in their conformational flexibility. When developing modulators, the structural modifications brought about by reaction intermediates are factored in to optimize activity and selectivity.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
P03950
UPID:
ANGI_HUMAN
Alternative names:
Ribonuclease 5
Alternative UPACC:
P03950; Q05CV1; Q53X86; Q6P5T2; Q8WXE7
Background:
Angiogenin, also known as Ribonuclease 5, plays a pivotal role in cellular stress response by cleaving tRNA to produce stress-induced fragments. These fragments inhibit protein synthesis and facilitate the assembly of stress granules, crucial for cell survival under adverse conditions. Additionally, angiogenin's involvement in vascularization and ribosomal RNA synthesis underscores its significance in both normal and pathological tissue development.
Therapeutic significance:
Given its role in the pathogenesis of Amyotrophic Lateral Sclerosis 9 (ALS9), where it's associated with genetic variants affecting its gene, angiogenin represents a promising target for therapeutic intervention. Understanding the multifaceted functions of angiogenin could pave the way for novel treatments for ALS9, a devastating neurodegenerative disorder.