Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
Our top-notch dedicated system is used to design specialised libraries for receptors.
Fig. 1. The sreening workflow of Receptor.AI
It features thorough molecular simulations of the receptor within its native membrane environment, complemented by ensemble virtual screening that considers its conformational mobility. For dimeric or oligomeric receptors, the full functional complex is constructed, and tentative binding sites are determined on and between the subunits to cover the entire spectrum of potential mechanisms of action.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
P04150
UPID:
GCR_HUMAN
Alternative names:
Nuclear receptor subfamily 3 group C member 1
Alternative UPACC:
P04150; A0ZXF9; B0LPG8; D3DQF4; F5ATB7; P04151; Q53EP5; Q6N0A4
Background:
The Glucocorticoid Receptor, encoded by the gene P04150, is a pivotal protein in mediating the effects of glucocorticoids. It functions as a transcription factor, binding to glucocorticoid response elements in DNA, influencing inflammatory responses, cellular proliferation, and differentiation. Additionally, it plays roles in chromatin remodeling, rapid mRNA degradation, and may act as a tumor suppressor.
Therapeutic significance:
Linked to the disease Glucocorticoid resistance, generalized, the Glucocorticoid Receptor's aberrations result in altered cortisol levels, impacting metabolic processes and stress responses. Understanding its mechanisms opens avenues for targeted therapies in cortisol-related disorders, offering hope for personalized medicine in combating these conditions.