Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We utilise our cutting-edge, exclusive workflow to develop focused libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
The method includes detailed molecular simulations of the catalytic and allosteric binding pockets, along with ensemble virtual screening that considers their conformational flexibility. In the design of modulators, structural changes induced by reaction intermediates are taken into account to enhance activity and selectivity.
Key features that set our library apart include:
partner
Reaxense
upacc
P05089
UPID:
ARGI1_HUMAN
Alternative names:
Liver-type arginase; Type I arginase
Alternative UPACC:
P05089; A6NEA0; Q5JWT5; Q5JWT6; Q8TE72; Q9BS50
Background:
Arginase-1, also known as Liver-type arginase or Type I arginase, plays a pivotal role in the urea cycle by converting L-arginine into urea and L-ornithine. This process is crucial for detoxifying ammonia in the liver, with implications for metabolic processes in the kidneys. Beyond its metabolic function, Arginase-1 is integral to immune response regulation, competing with nitric oxide synthase for arginine, influencing T cell and NK cell activities, and supporting type 2 inflammation in the lung.
Therapeutic significance:
Arginase-1's malfunction is directly linked to Argininemia, a rare autosomal recessive disorder characterized by elevated arginine levels, developmental delays, and severe neurological symptoms. Understanding the role of Arginase-1 could open doors to potential therapeutic strategies, offering hope for targeted treatments that could alleviate or even prevent the debilitating effects of Argininemia.