Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We use our state-of-the-art dedicated workflow for designing focused libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
It includes comprehensive molecular simulations of the catalytic and allosteric binding pockets and the ensemble virtual screening accounting for their conformational mobility. In the case of designing modulators, the structural changes induced by reaction intermediates are taken into account to leverage activity and selectivity.
Our library stands out due to several important features:
partner
Reaxense
upacc
P06239
UPID:
LCK_HUMAN
Alternative names:
Leukocyte C-terminal Src kinase; Lymphocyte cell-specific protein-tyrosine kinase; Protein YT16; Proto-oncogene Lck; T cell-specific protein-tyrosine kinase; p56-LCK
Alternative UPACC:
P06239; D3DPP8; P07100; Q12850; Q13152; Q5TDH8; Q5TDH9; Q7RTZ3; Q96DW4; Q9NYT8
Background:
Tyrosine-protein kinase Lck, also known as p56-LCK, plays a pivotal role in T-cell development and activation. It is involved in the signal transduction pathways linked to the T-cell receptor (TCR), contributing to the maturation of developing T-cells in the thymus and the function of mature T-cells. Lck phosphorylates key tyrosine residues, initiating the TCR/CD3 signaling pathway, essential for lymphokine production and T-cell proliferation.
Therapeutic significance:
Given its crucial role in T-cell function, Lck is implicated in Immunodeficiency 22, a disease characterized by T-cell dysfunction, lymphopenia, and recurrent infections. Targeting Lck offers a promising strategy for therapeutic intervention in T-cell related disorders, potentially restoring immune system functionality and providing relief for affected individuals.