Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We employ our advanced, specialised process to create targeted libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
The procedure entails thorough molecular simulations of the catalytic and allosteric binding pockets, accompanied by ensemble virtual screening that factors in their conformational flexibility. When developing modulators, the structural modifications brought about by reaction intermediates are factored in to optimize activity and selectivity.
Key features that set our library apart include:
partner
Reaxense
upacc
P07098
UPID:
LIPF_HUMAN
Alternative names:
-
Alternative UPACC:
P07098; B7Z723; F5H1P4; Q2M1P6; Q5VXI7; Q5VXI8; Q658L8
Background:
Gastric triacylglycerol lipase plays a crucial role in lipid metabolism by catalyzing the hydrolysis of triacylglycerols into free fatty acids, diacylglycerol, monoacylglycerol, and glycerol. This enzyme exhibits a preference for acting at the sn-3 position of triacylglycerol, highlighting its specificity in lipid digestion processes.
Therapeutic significance:
Understanding the role of Gastric triacylglycerol lipase could open doors to potential therapeutic strategies. Its pivotal function in lipid metabolism makes it a compelling target for addressing disorders related to lipid digestion and absorption.