Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
P08134
UPID:
RHOC_HUMAN
Alternative names:
Rho cDNA clone 9
Alternative UPACC:
P08134; B3KSW1; Q6ICN3
Background:
The Rho-related GTP-binding protein RhoC, also known as Rho cDNA clone 9, plays a pivotal role in cellular processes. It regulates signal transduction pathways that connect plasma membrane receptors with the formation of focal adhesions and actin stress fibers. Additionally, RhoC is essential for myosin contractile ring formation during cell cycle cytokinesis and is involved in apical junction formation in bronchial epithelial cells.
Therapeutic significance:
Understanding the role of Rho-related GTP-binding protein RhoC could open doors to potential therapeutic strategies. Its involvement in critical cellular processes suggests that modulating its activity could offer new avenues for treating diseases related to cell division and epithelial cell function.