Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We use our state-of-the-art dedicated workflow for designing focused libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
It includes in-depth molecular simulations of both the catalytic and allosteric binding pockets, with ensemble virtual screening focusing on their conformational flexibility. For modulators, the process includes considering the structural shifts due to reaction intermediates to boost activity and selectivity.
Several key aspects differentiate our library:
partner
Reaxense
upacc
P08581
UPID:
MET_HUMAN
Alternative names:
HGF/SF receptor; Proto-oncogene c-Met; Scatter factor receptor; Tyrosine-protein kinase Met
Alternative UPACC:
P08581; A1L467; B5A932; E7EQ94; O60366; Q12875; Q9UDX7; Q9UPL8
Background:
The Hepatocyte growth factor receptor, known by its aliases such as HGF/SF receptor, Proto-oncogene c-Met, Scatter factor receptor, and Tyrosine-protein kinase Met, plays a pivotal role in various physiological processes. It transduces signals from the extracellular matrix to the cytoplasm by binding to its ligand, HGF, influencing cell proliferation, survival, and morphogenesis. Its activation triggers multiple signaling cascades crucial for embryonic development, organ regeneration, and tissue remodeling.
Therapeutic significance:
Given its involvement in diseases like Hepatocellular carcinoma, Renal cell carcinoma papillary, and Osteofibrous dysplasia, targeting the Hepatocyte growth factor receptor presents a promising avenue for therapeutic intervention. Its role in these conditions underscores the potential for developing targeted therapies that could inhibit its activity, offering hope for patients suffering from these malignancies.