Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
P09038
UPID:
FGF2_HUMAN
Alternative names:
Basic fibroblast growth factor; Heparin-binding growth factor 2
Alternative UPACC:
P09038; A4LBB8; O00527; P78443; Q16443; Q5PY50; Q7KZ11; Q7KZ72; Q9UC54; Q9UCS5; Q9UCS6
Background:
Fibroblast growth factor 2 (FGF2), also known as basic fibroblast growth factor and heparin-binding growth factor 2, is a multifunctional protein with a pivotal role in various biological processes. It serves as a ligand for FGFR1-4, facilitating FGF2 signaling through integrin ITGAV:ITGB3 interaction. FGF2 is instrumental in cell survival, division, differentiation, and migration, showcasing its potency as a mitogen and its capability to induce angiogenesis. Additionally, it mediates ERK1/2 phosphorylation, promoting retinal lens fiber differentiation.
Therapeutic significance:
Understanding the role of Fibroblast growth factor 2 could open doors to potential therapeutic strategies.