Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We use our state-of-the-art dedicated workflow for designing focused libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
The method includes detailed molecular simulations of the catalytic and allosteric binding pockets, along with ensemble virtual screening that considers their conformational flexibility. In the design of modulators, structural changes induced by reaction intermediates are taken into account to enhance activity and selectivity.
Key features that set our library apart include:
partner
Reaxense
upacc
P09104
UPID:
ENOG_HUMAN
Alternative names:
2-phospho-D-glycerate hydro-lyase; Enolase 2; Neural enolase; Neuron-specific enolase
Alternative UPACC:
P09104; B7Z2X9; Q96J33
Background:
Gamma-enolase, also known as Neuron-specific enolase, plays a pivotal role in the central nervous system's neuronal development. It is recognized for its neurotrophic and neuroprotective properties, binding to neocortical neurons in a calcium-dependent manner to promote cell survival. This protein, alternatively named 2-phospho-D-glycerate hydro-lyase, Enolase 2, and Neural enolase, is essential for neuronal health and function.
Therapeutic significance:
Understanding the role of Gamma-enolase could open doors to potential therapeutic strategies. Its ability to support neuron survival suggests its significance in neurodegenerative disease research and therapy development, offering a promising avenue for future investigations.