Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
Our top-notch dedicated system is used to design specialised libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
It includes comprehensive molecular simulations of the catalytic and allosteric binding pockets and the ensemble virtual screening accounting for their conformational mobility. In the case of designing modulators, the structural changes induced by reaction intermediates are taken into account to leverage activity and selectivity.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
P10153
UPID:
RNAS2_HUMAN
Alternative names:
Eosinophil-derived neurotoxin; RNase UpI-2; Ribonuclease 2; Ribonuclease US
Alternative UPACC:
P10153; Q52M39; Q9H2B7; Q9UCG7
Background:
The Non-secretory ribonuclease, also known as Eosinophil-derived neurotoxin, RNase UpI-2, Ribonuclease 2, and Ribonuclease US, is a pyrimidine-specific nuclease with a preference for uracil. It exhibits cytotoxic and helminthotoxic properties and is selectively chemotactic for dendritic cells. Its broad biological activities highlight its significance in various physiological processes.
Therapeutic significance:
Understanding the role of Non-secretory ribonuclease could open doors to potential therapeutic strategies. Its ability to target dendritic cells and its wide range of biological activities make it a promising candidate for the development of novel treatments.