Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We use our state-of-the-art dedicated workflow for designing focused libraries for receptors.
Fig. 1. The sreening workflow of Receptor.AI
This process includes extensive molecular simulations of the receptor in its native membrane environment, along with ensemble virtual screening that accounts for its conformational mobility. In the case of dimeric or oligomeric receptors, the entire functional complex is modelled, identifying potential binding pockets on and between the subunits to encompass all possible mechanisms of action.
Several key aspects differentiate our library:
partner
Reaxense
upacc
P10912
UPID:
GHR_HUMAN
Alternative names:
Somatotropin receptor
Alternative UPACC:
P10912; Q9HCX2
Background:
The Growth Hormone Receptor (GHR), also known as Somatotropin receptor, plays a pivotal role in regulating postnatal body growth. It functions by binding to the pituitary gland growth hormone, activating the JAK2/STAT5 pathway. Additionally, its soluble form (GHBP) serves as a growth hormone reservoir in plasma, potentially modulating GH signaling.
Therapeutic significance:
GHR is implicated in Laron syndrome and partial growth hormone insensitivity, both of which involve growth impairment and short stature due to dysfunctional GHR. Understanding the role of Growth Hormone Receptor could open doors to potential therapeutic strategies for these conditions.