Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
P12074
UPID:
CX6A1_HUMAN
Alternative names:
Cytochrome c oxidase polypeptide VIa-liver; Cytochrome c oxidase subunit VIA-liver
Alternative UPACC:
P12074; B2R500; O43714; Q32Q37
Background:
Cytochrome c oxidase subunit 6A1, mitochondrial, also known as Cytochrome c oxidase polypeptide VIa-liver, plays a pivotal role in the mitochondrial electron transport chain. This enzyme is integral to the process of oxidative phosphorylation, facilitating the transfer of electrons from NADH and succinate to molecular oxygen. This action is crucial for the generation of ATP, the energy currency of the cell, highlighting the protein's essential role in cellular metabolism and energy production.
Therapeutic significance:
The association of Cytochrome c oxidase subunit 6A1 with Charcot-Marie-Tooth disease, recessive intermediate D, underscores its clinical relevance. This connection suggests that targeted research into this protein's function and pathological variants could yield novel therapeutic strategies for managing this peripheral nervous system disorder, characterized by muscle weakness and atrophy.