Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
P12104
UPID:
FABPI_HUMAN
Alternative names:
Fatty acid-binding protein 2; Intestinal-type fatty acid-binding protein
Alternative UPACC:
P12104; Q2NKJ1
Background:
Fatty acid-binding protein 2 (FABP2), also known as Intestinal-type fatty acid-binding protein, plays a crucial role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. It is particularly involved in the synthesis of triglyceride-rich lipoproteins, binding saturated long-chain fatty acids with high affinity, while showing lower affinity for unsaturated ones. FABP2's function as a lipid sensor may also contribute to maintaining energy homeostasis.
Therapeutic significance:
Understanding the role of Fatty acid-binding protein, intestinal could open doors to potential therapeutic strategies.