Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We employ our advanced, specialised process to create targeted libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
The procedure entails thorough molecular simulations of the catalytic and allosteric binding pockets, accompanied by ensemble virtual screening that factors in their conformational flexibility. When developing modulators, the structural modifications brought about by reaction intermediates are factored in to optimize activity and selectivity.
Key features that set our library apart include:
partner
Reaxense
upacc
P12272
UPID:
PTHR_HUMAN
Alternative names:
Parathyroid hormone-like protein
Alternative UPACC:
P12272; Q15251; Q6FH74
Background:
Parathyroid hormone-related protein (PTHrP), also known as Parathyroid hormone-like protein, plays a pivotal role in the regulation of cellular and organ growth, development, migration, differentiation, and survival, as well as epithelial calcium ion transport. It is instrumental in endochondral bone development and the epithelial-mesenchymal interactions during mammary glands and teeth formation, ensuring skeletal homeostasis and promoting mammary mesenchyme differentiation.
Therapeutic significance:
PTHrP's involvement in Brachydactyly E2, a condition characterized by the shortening of digits due to abnormal development, underscores its therapeutic potential. Understanding the role of Parathyroid hormone-related protein could open doors to potential therapeutic strategies, especially in bone development disorders and epithelial-mesenchymal interaction-related conditions.