Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
P13645
UPID:
K1C10_HUMAN
Alternative names:
Cytokeratin-10; Keratin-10
Alternative UPACC:
P13645; Q14664; Q8N175
Background:
Keratin, type I cytoskeletal 10, also known as Cytokeratin-10 or Keratin-10, plays a crucial role in the establishment and maintenance of the epidermal barrier, particularly in plantar skin. It is involved in cell layer development and the formation of keratin filament bundles in epithelial cells, ensuring the integrity of the skin's protective layer.
Therapeutic significance:
Keratin-10's involvement in various skin disorders, including Epidermolytic hyperkeratosis, Ichthyosis with confetti, and Ichthyosis histrix, Lambert type, underscores its potential as a target for therapeutic intervention. Understanding the role of Keratin-10 could open doors to potential therapeutic strategies for these debilitating conditions.