Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We use our state-of-the-art dedicated workflow for designing focused libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
This approach involves comprehensive molecular simulations of the catalytic and allosteric binding pockets and ensemble virtual screening that accounts for their conformational flexibility. In the case of designing modulators, the structural adjustments caused by reaction intermediates are considered to improve activity and selectivity.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
P14384
UPID:
CBPM_HUMAN
Alternative names:
-
Alternative UPACC:
P14384; B2R800; Q9H2K9
Background:
Carboxypeptidase M, encoded by the gene with accession number P14384, is a pivotal enzyme that specifically targets and removes C-terminal basic residues, such as Arginine (Arg) or Lysine (Lys), from peptides and proteins. This enzymatic activity is crucial for modulating the activity of peptide hormones and growth factors at the cellular surface, as well as for the degradation of extracellular proteins localized to the membrane.
Therapeutic significance:
Understanding the role of Carboxypeptidase M could open doors to potential therapeutic strategies. Its unique enzymatic function suggests its involvement in critical regulatory processes, making it a promising target for drug discovery efforts aimed at modulating peptide hormone and growth factor activities for therapeutic purposes.