Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
Our high-tech, dedicated method is applied to construct targeted libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
It includes comprehensive molecular simulations of the catalytic and allosteric binding pockets and the ensemble virtual screening accounting for their conformational mobility. In the case of designing modulators, the structural changes induced by reaction intermediates are taken into account to leverage activity and selectivity.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
P15374
UPID:
UCHL3_HUMAN
Alternative names:
Ubiquitin thioesterase L3
Alternative UPACC:
P15374; B2R970; Q5TBK8; Q6IBE9
Background:
Ubiquitin carboxyl-terminal hydrolase isozyme L3, also known as Ubiquitin thioesterase L3, plays a pivotal role in cellular processes by controlling ubiquitin levels. It processes ubiquitin precursors and ubiquitinated proteins, favoring 'Lys-48'-linked ubiquitin chains. This enzyme is crucial for the regulation of insulin signaling, adipogenesis, and the maintenance of retinal, skeletal muscle, and germ cells. It also has implications in memory function.
Therapeutic significance:
Understanding the role of Ubiquitin carboxyl-terminal hydrolase isozyme L3 could open doors to potential therapeutic strategies.