Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We use our state-of-the-art dedicated workflow for designing focused libraries for receptors.
Fig. 1. The sreening workflow of Receptor.AI
This includes comprehensive molecular simulations of the receptor in its native membrane environment, paired with ensemble virtual screening that factors in its conformational mobility. In cases involving dimeric or oligomeric receptors, the entire functional complex is modelled, pinpointing potential binding pockets on and between the subunits to capture the full range of mechanisms of action.
Key features that set our library apart include:
partner
Reaxense
upacc
P15692
UPID:
VEGFA_HUMAN
Alternative names:
Vascular permeability factor
Alternative UPACC:
P15692; B5BU86; H0Y2S8; H0Y407; H0Y414; H0Y462; H0Y8N2; H3BLW7; O60720; O75875; Q074Z4; Q16889; Q5UB46; Q6P0P5; Q96KJ0; Q96L82; Q96NW5; Q9H1W8; Q9H1W9; Q9UH58; Q9UL23
Background:
Vascular endothelial growth factor A, long form, also known as Vascular permeability factor, plays a pivotal role in angiogenesis, vasculogenesis, and endothelial cell growth. It activates key pathways by binding to receptors such as FLT1/VEGFR1, KDR/VEGFR2, and NRP1/neuropilin-1, promoting cell migration, proliferation, and survival while inhibiting apoptosis.
Therapeutic significance:
Given its involvement in microvascular complications of diabetes, including diabetic retinopathy, nephropathy, and neuropathy, understanding the role of Vascular endothelial growth factor A could open doors to potential therapeutic strategies for managing diabetes-related vascular issues.