Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
P17661
UPID:
DESM_HUMAN
Alternative names:
-
Alternative UPACC:
P17661; Q15787; Q549R7; Q549R8; Q549R9; Q8IZR1; Q8IZR6; Q8NES2; Q8NEU6; Q8TAC4; Q8TCX2; Q8TD99; Q9UHN5; Q9UJ80
Background:
Desmin, a muscle-specific type III intermediate filament, is pivotal in maintaining muscular structure and function. It interconnects Z-disks, forms myofibrils, and links them to the sarcolemmal cytoskeleton, nucleus, and mitochondria, providing strength during muscle activity. Desmin's association with detyrosinated tubulin-alpha chains suggests a role as a sarcomeric microtubule-anchoring protein.
Therapeutic significance:
Mutations in the DES gene, encoding Desmin, are linked to a spectrum of muscle and cardiac diseases, including myofibrillar myopathy, dilated cardiomyopathy, and neurogenic scapuloperoneal syndrome Kaeser type. Understanding Desmin's role could lead to targeted therapies for these conditions.