Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our top-notch dedicated system is used to design specialised libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
The procedure entails thorough molecular simulations of the catalytic and allosteric binding pockets, accompanied by ensemble virtual screening that factors in their conformational flexibility. When developing modulators, the structural modifications brought about by reaction intermediates are factored in to optimize activity and selectivity.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
P17752
UPID:
TPH1_HUMAN
Alternative names:
Tryptophan 5-monooxygenase 1
Alternative UPACC:
P17752; D3DQX6; O95188; O95189; Q16736; Q3KPG8
Background:
Tryptophan 5-hydroxylase 1, also known as Tryptophan 5-monooxygenase 1, plays a pivotal role in serotonin biosynthesis. It catalyzes the conversion of L-tryptophan to 5-hydroxy-l-tryptophan, a critical step in the production of serotonin, a neurotransmitter essential for maintaining mood balance.
Therapeutic significance:
Understanding the role of Tryptophan 5-hydroxylase 1 could open doors to potential therapeutic strategies. Its central function in serotonin production makes it a target of interest in the treatment of disorders related to serotonin imbalance, such as depression and anxiety.