Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
P18085
UPID:
ARF4_HUMAN
Alternative names:
-
Alternative UPACC:
P18085; B2R7J7; P21371
Background:
ADP-ribosylation factor 4 (ARF4) is a pivotal GTP-binding protein, serving as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. It plays a crucial role in protein trafficking, potentially influencing vesicle budding and uncoating within the Golgi apparatus. Its involvement in these cellular processes underscores its importance in maintaining cellular function and integrity.
Therapeutic significance:
Understanding the role of ADP-ribosylation factor 4 could open doors to potential therapeutic strategies. Its central role in protein trafficking and modulation within the Golgi apparatus highlights its potential as a target for therapeutic intervention in diseases where protein trafficking is compromised.